Quality control of pharmaceutical products

The manufacturing of pharmaceutical products ist a complex and costly process. The high quality requirements related to this industry must be met along the full production line, especially during the critical processes. Furthermore, the final product needs to be checked for quality failures, missing product, false contents…

Multispectral and hyperspectral analysis are the ideal tools for monitoring manufacturing processes where pull samples cannot be used (for practical reasons or due to the high costs of the product). Those light-based methods are non-destructive and have the capability to provide high-content data at a rate compatible with industrial production.

For example, a hyperspectral camera can be used in the production line of transdermal patches for the monitoring of nonuniformities in the active pharmaceutical ingredient (API). Packaged product can be analysed for missing or false contents. Similar-looking tablets can be sorted using chemical imaging (Fig.1).

Fig. 1 Study of a mix of tablets using hyperspectral scanning system ProScan-HSI

At the single-tablet level, it is possible to use high spatial resolution hyperspectral imaging for monitoring the spatial distribution and statistic size distribution of the API (Fig.2).

Fig. 2 Hyperspectral analysis of a single tablet using uniSPEC1.7HSI